Effect of Ziyinqingsang decoction on interleukin-4 and -5 levels in peripheral blood mononuclear cells of children in acute stage of cough variant asthma.
- Author:
Yin ZHANG
1
;
Chen FENG
;
Ke CAO
Author Information
- Publication Type:Journal Article
- MeSH: Asthma; blood; drug therapy; Child; Cough; blood; drug therapy; Drugs, Chinese Herbal; therapeutic use; Female; Humans; Interleukin-4; blood; Interleukin-5; blood; Leukocytes, Mononuclear; Male; Phytotherapy
- From: Journal of Southern Medical University 2011;31(4):707-708
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of Ziyinqingsang decoction on the levels of interleukin-4 (IL-4) and IL-5 in the peripheral blood mononuclear cells (PBMCs) in children with cough variant asthma (CVA) in the acute stage.
METHODSThirty children with CVA in the acute stage were given Ziyinqingsang decoction for 2 weeks. The IL-4 and IL-5 levels in the PBMCs were determined using ELISA before and after the treatment, and the changes of the clinical symptoms were observed.
RESULTSThe levels of IL-4 and IL-5 in the PBMCs was 89.69∓13.82 ng/l and 12.17∓0.43 ng/ml before the treatment, which were significantly reduced to 72.18∓14.89 ng/l and 5.81∓0.31 ng/ml after the treatment (P<0.05). The symptoms including coughing, pharyngodynia, and pharyngo-itch were all improved obviously (P<0.05).
CONCLUSIONZiyinqingsang decoction ameliorates the symptoms of CVA in the acute stage probably by decreasing the levels of IL-4 and IL-5 in the PBMCs of the children.
