Inflammatory and Tumor Stimulating Responses after Laparoscopic Sigmoidectomy.
10.3349/ymj.2011.52.4.635
- Author:
Jin Soo KIM
1
;
Hyuk HUR
;
Byung Soh MIN
;
Kang Young LEE
;
Hyun Cheol CHUNG
;
Nam Kyu KIM
Author Information
1. Department of Surgery, Chungnam National University Hospital, Daejeon, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
- Keywords:
Colon neoplasm;
laparoscopic surgery;
acute inflammation;
tumor stimulation
- MeSH:
Aged;
Biological Markers/blood;
C-Reactive Protein/metabolism;
Colectomy/*adverse effects/methods;
Female;
Humans;
Inflammation/etiology/metabolism;
Insulin-Like Growth Factor Binding Protein 3/blood;
Interleukin-6/blood;
Laparoscopy/adverse effects;
Male;
Middle Aged;
Postoperative Period;
Sigmoid Neoplasms/*surgery;
Treatment Outcome;
Vascular Endothelial Growth Factor A/blood
- From:Yonsei Medical Journal
2011;52(4):635-642
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Laparoscopic colectomy has clinical benefits such as short hospital stay, less postoperative pain, and early return of bowel function. However, objective evidence of its immunologic and oncologic benefits is scarce. We compared functional recovery after open versus laparoscopic sigmoidectomy and investigated the effect of open versus laparoscopic surgery on acute inflammation as well as tumor stimulation. MATERIALS AND METHODS: A total of 57 patients who were diagnosed with sigmoid colon cancer were randomized for elective conventional or laparoscopically assisted sigmoidectomy. Serum samples were obtained preoperatively and on postoperative day 1. C-reactive protein (CRP) and interleukin-6 (IL-6) were measured as inflammation markers, and vascular endothelial growth factor (VEGF) and insulin-like growth factor binding protein-3 (IGFBP-3) were used as tumor stimulation factors. Clinical parameters and serum markers were compared. RESULTS: Postoperative hospital stay (p=0.031), the first day of gas out (p=0.016), and the first day of soft diet (p<0.001) were significantly shorter for the laparoscopic surgery group than the open surgery group. The levels of CRP, IL-6, and VEGF rose significantly, and the concentration of IGFBP-3 fell significantly after both open and laparoscopic surgery. However, there were no significant differences in the preoperative and postoperative levels of CRP, IL-6, VEGF, and IGFBP-3 between the two groups. CONCLUSION: Our data suggest that both open and laparoscopic surgeries are accompanied by significant changes in IL-6, CRP, IGFBP-3, and VEGF levels. Acute inflammation markers and tumor stimulating factors may not reflect clinical benefits of laparoscopic surgery.
