Expression of Oct-4 transcription factor in squamous cell skin carcinoma and seborrheic keratosis.
- Author:
Yu-yang LI
1
;
Yong-jiang DAI
;
Bin DENG
;
Xiong-an LIANG
;
Zhi-jie XIE
;
Hai-fu CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma, Squamous Cell; metabolism; pathology; Case-Control Studies; Female; Humans; Keratosis, Seborrheic; metabolism; pathology; Male; Middle Aged; Octamer Transcription Factor-3; metabolism; Skin Neoplasms; metabolism; pathology; Young Adult
- From: Journal of Southern Medical University 2011;31(5):917-918
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the expression of stem cell transcription factor Oct-4 in squamous cell carcinoma (SCC) and seborrheic keratosis (SK) and its association with cancer stem cells.
METHODSImmunohistochemistry was used to detect Oct-4 expression in 35 SCC cases, 21 SK cases and 15 normal control skin tissues.
RESULTSOct-4 expression was negative in normal skin and showed a significant difference between SCC and SK tissues (P<0.05).
CONCLUSIONThe Oct-4-positive cells in SCC and SK are probably tumor stem cells. Oct-4 expression may provide an important evidence for isolation and identification of human SCC and SK stem cells.
