Level and clinical significance of soluble CD40 in patients with chronic hepatitis B

VernacularTitle:慢性乙型肝炎患者血清中可溶性CD40的检测及其临床意义
Author: Hong-Hui SHEN ¹ ; Hong-Yan SUN ; Jing-Min ZHAO ; Jun HOU ; Bing-Ke BAI ; Yan HU ; Wei KONG ; Pan-Yong MAO
Author Information

1. 解放军第302医院
Keywords: Hepatitis B; chronic; Antigens; CD40; Inflammation
From: Chinese Journal of Experimental and Clinical Virology 2008;22(5):373-375
CountryChina
Language:Chinese
Abstract: Objective To understand the level and clinical significance of soluble CD40 in patients with chronic hepatitis B. Methods Detecting the concentration of sCD40 from 176 eases with chronic hepatitis B by ELISA and analyzing its relationship with different grades of inflammation and necrosis in liver tissue. Results sCD40 from patients with chronic hepatitis B was significantly higher than those from healthy. And that the concentration of sCD40 was positive correlation with severe clinical disease and liver inflammation and necrosis. In patients whose ALT lower than 80 IU/L and sCD40 higher than 80 pg/ml, it showed that 65.85% cases have high grade of liver inflammation and necrosis, which was significantly higher than patients with sCD40 lower than 80 pg/ ml. Conclusion The concentration of sCD40 is positively related with the grade of liver inflammation and necrosis. This information could help us to evaluate the status of chronic hepatitis B as an immunological index.