Relationships between liver function test, serum HBeAg or HBV DNA level and liver pathological changes inpatients with chronic hepatitis B
10.3760/cma.j.issn.1003-9279.2008.06.008
- VernacularTitle:慢性乙型肝炎患者肝功能及血清HBeAg和HBV DNA载量与肝组织病理相关性的研究
- Author:
Qi-Huan XU
1
;
Xin SHU
;
Lu-Biao CHEN
;
Hai-Hui HUANG
;
Ka ZHANG
;
Guang LI
Author Information
1. 中山大学附属第三医院
- Keywords:
Hepatitis B;
Histopathology;
laver function;
Hepatitis B virus;
DNA;
Hepatitis B e antigens
- From:
Chinese Journal of Experimental and Clinical Virology
2008;22(6):422-424
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study was to investigate the relationship between liver function test,serum HBeAg,HBV DNA level and liver pathological changes in patients with chronic hepatitis B.Methods 233 patients with chronic hepatitis B accept liver functure biopsy,liver function test,HBeAg detection and HBV DNA fluorescent quantitation PCR detection. Comparisons of liver function test,HBeAg and HBV DNA level were conducted among different liver pathological changes including inflammation grading and fibrosis staging. Results In different inflammation grading groups,ALT was highest in group G3 and lowest in group G0-1 ( P = 0.016) ;TBil was highest in group G4 and lowest in group G0-1 (P = 0.000);HBV DNA level was highest in group G4 and lowest in group G0-1 ,but not statistically significant among groups ( P = 0.463). in different fibrosis staging groups,ALT was highest in group S3 and lowest in group S0-1 ,but not statistically significant among groups (P = 0.562) ;TBil was highest in group S4 and lowest in group S2 ( P = 0.039) ; HBV DNA level was highest in group S3 and lowest in group S0-1 ,but not statistically significant among groups ( P = 0.395). In HBeAg positive group,the proportion of G3-4 in inflammation grading or S3-4 in fibrosis staging was lower than that in HBeAg negative group (46% vs 52%,P = 0.438;38 % vs 53 %,P = 0.025 ;respectively). Conclusion HBV DNA level can not indicate the severity of liver inflammation or fibrosis in chronic HBV infection. Patients with HBeAg negative often are complicated with more severity of liver fibrosis. In routine liver function test,TBil level eorrelates with hver inflammation grading or fibrosis staging; ALT level also correlates with liver inflammation grading but not with fibrosis staging.
