The expression of apoptosis related genes Bcl-2 and Bax protein in dysfunctional uterine bleeding.
- Author:
Li-li ZHOU
1
;
Li-na YANG
;
Li WANG
Author Information
- Publication Type:Journal Article
- MeSH: Apoptosis; physiology; Endometrium; metabolism; Female; Gene Expression; Humans; Hyperplasia; metabolism; pathology; Metrorrhagia; genetics; metabolism; pathology; Proto-Oncogene Proteins c-bcl-2; genetics; metabolism; Uterine Neoplasms; metabolism; pathology; bcl-2-Associated X Protein; metabolism
- From: Chinese Journal of Experimental and Clinical Virology 2008;22(6):455-457
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo research the expression of apoptosis related genes Bcl-2 and Bax protein in dysfunctional uterine bleeding.
METHODSDetecting the expression of Bcl-2 and Bax protein in 40 cases of endometrium tissue of dysfunctional uterine bleeding patients with immunohistochemistry antibiotics protein-peroxide emzyme (SP)methods.
RESULTS(1) The expression of Bcl-2 protein changes clearly and periodically in endometrium in normal cycle, the difference is obvious (P < 0.05). (2) The Bcl-2 protein develops with the hyperplasia in endometrium and the expression intensity is enhanced, the difference is obvious( P < 0.05). (3) The expression of Bax gene is masculine in endometrium in normal menstrual cycle. (4) The expression of Bax gene descends gradually with hyperplasia in uterine endometrium (P < 0.05).
CONCLUSIONApoptosis of endometrium cell is restrained from the excessive expression of Bcl-2 protein and deficient expression of Bax protein, so the uterine endometrium gets to hyperplasia or notypical hyperplasia.
