Relationship between EB virus, Cytomegalo virus, herpes simplex virus and coxsackievirus infection and relapse of multiple sclerosis
10.3760/cma.j.issn.1003-9279.2008.06.024
- VernacularTitle:EB病毒、巨细胞病毒、单纯疱疹病毒和柯萨奇病毒感染和多发性硬化复发关系的研究
- Author:
Zi-Jing FENG
1
;
Ri-Guang ZHAO
;
De-Xin WANG
Author Information
1. 首都医科大学附属北京友谊医院
- Keywords:
Enterovirus B,human;
Herpesvirus 4,human;
Cytomegalovirus;
Simplexvirus;
Relapsing-remitting multiple sclerosis
- From:
Chinese Journal of Experimental and Clinical Virology
2008;22(6):472-474
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relation between the recent active infection with Epstein-Barr virus,cytomegalovirus,herpes simplex virns-1,coxsackievirus B Ⅰ-Ⅳ and the relapse of relapsing-remitting multiple sclerosis (RR MS). Methods Using ELISA method,IgM antibodies to Epstein-Barr virus,eytomegalovirus,herpes simplex rims-1,coxsackievirus B Ⅰ-Ⅳ in the plasma from 34 RR MS patients and 200 normal controls were detected. The rates of recent active infection with the above mentioned viruses of the patients and controls were compared. For patients group,comparison was also made between the clinical data of recent active infected patients and patients without recent active infection. Results There was no statistically significant difference in positive rates of positive rates of IgM antibodies against Epstein-Barr virus,cytomegalovirus,herpes simplex virus-1 and eoxsackievirus B Ⅰ ,Ⅱ ,Ⅲ or Ⅵ between the two groups. While there was statistically significant difference in positive rates of IgM antibodies to coxsackievirus B Ⅵ and Ⅴ in the RR MS patients and those in the controls (being 3/34 and 0/200 P < 0.05;2/34 and 0/200 P < 0.05,respectively). In the patient group,when patients who had active infection with any of the viruses were compared with those who had no active infection,no significant difference between them was found in terms of age,course,frequency,body temperature on admission,differential leukocyte count (neutrophilic granulocyte,lymphocyte and monocytes),use of glucocorticoids,and EDSS point value. Conclusions There is a high rate of recent active infection with coxsackievirus B Ⅵ and Ⅴ in RR MS patients at relapsing stage. While the recent virus active infection is unrelated to the severity of the symptoms.
