In vitro inhibitory mechanism of respiratory syncytial virus with solution prescription of zhidanhuayu.
- Author:
Yu-hua LIU
1
;
An-cun HOU
;
Gao-chao ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antiviral Agents; adverse effects; therapeutic use; Cell Line; Cells, Cultured; Cercopithecus aethiops; Drugs, Chinese Herbal; adverse effects; therapeutic use; Respiratory Syncytial Virus Infections; drug therapy; Respiratory Syncytial Viruses; drug effects; physiology; Vero Cells; drug effects; physiology; Virus Replication; drug effects
- From: Chinese Journal of Experimental and Clinical Virology 2008;22(6):486-487
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effective part of solution prescription of Zhidanhuayu (ZDHY) against respiratory syncytial virus (RSV) in vitro.
METHODSObserve the pathology of RSV to Hep-2 under the condition of different concentrations and each effective part of ZDHY.
RESULTSThe concentration limit causing celluar toxicity of ZDHY is 5.5 mg/ml. The ZDHY failed to block the absorption of RSV to Hep-2 within this concentration, and consequently the cell fell into the full pathological changes. During the concentration of 2.75-5.50 mg/ml, the ZDHY directly destroyed virus array,meanwhile, the infected cells that treated by the medicine kept healthy also.
CONCLUSIONZDHY could not defend the infection of RSV, but is able to destroy the RSV directly and inhibit the RSV inhabiting in the cell.
