In vitro inhibitory mechanism of respiratory syncytial virus with solution prescription of Zhidanhuayu

VernacularTitle:蛭丹化瘀口服液体外抑制RSV作用机制的研究
Author: Yu-Hua LIU ¹ ; An-Cun HOU ; Gao-Chao ZHAO
Author Information

1. 首都医科大学附属北京友谊医院
Keywords: Drugs,Chines herbal; Respiratory syncytial virus; Solution prescription of Zhidanhuayu
From: Chinese Journal of Experimental and Clinical Virology 2008;22(6):486-487
CountryChina
Language:Chinese
Abstract: Objective To study the effective part of solution prescription of Zhidanhuayu(ZDHY) against respiratory syncytial virus (RSV) in vitro. Methods Observe the pathology of RSV to Hep-2 under the condition of different concentrations and each effective part of ZDHY. Results The concentration limit causing celluar toxicity of ZDHY is 5.5 mg/ml. The ZDHY failed to block the absorption of RSV to Hep-2 within this concentration,and consequently the cell fell into the full pathological changes. During the concentration of 2.75-5.50 mg/ml,the ZDHY directly destroyed virus array,meanwhile,the infected cells that treated by the medicine kept healthy also. Conclusion ZDHY could not defend the infection of RSV,but is able to destroy the RSV directly and inhibit the RSV inhabiting in the cell.