Investigating genotype of HCV distribution among residents in a "blood donation" village in Hebei Province.
- Author:
Chang-Hong HUANG
1
;
Ji-Kun ZHOU
;
Li LIU
;
Rong-Men JIANG
;
Yan-Qiang CAO
;
Zhen-Yun MU
;
Yong ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Blood Donors; Child; Child, Preschool; China; epidemiology; Female; Genotype; Hepacivirus; classification; genetics; isolation & purification; Hepatitis C; epidemiology; virology; Humans; Infant; Infant, Newborn; Male; Middle Aged; Molecular Sequence Data; Phylogeny; Young Adult
- From: Chinese Journal of Experimental and Clinical Virology 2009;23(1):8-10
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate genotype of HCV infection among residents in a rural village, Hebei Province.
METHODSBlood samples of the 520 residents were collected, and C/E1 of HCV genome of the 483 samples were obtained by RT-PCR amplifying, and the gene sequences were analyzed and the polygenetic tree were drawn by the software Mega 4.0.
RESULTSIn 483 subjects, HCV-RNA positive objectives are 70, positive prevalence is 14.5%, genotyping for all the samples successfully, including genotypes 1b and 2a, which are 36 (51.4%), 34 (48.6%) respectively.
CONCLUSIONHCV RNA positive rate is 14.5%, which is higher than general people. Subtypes 1b and 2a seemed to be the dominant genotypes of HCV in Zhao county area of Hebei Province.
