Investigating genotype of HCV distribution among residents in a "blood donation" village in Hebei Province
10.3760/cma.j.issn.1003-9279.2009.01.004
- VernacularTitle:河北某非法采血村人群感染HCV基因亚型调查
- Author:
Chang-Hong HUANG
1
;
Ji-Kun ZHOU
;
Li LIU
;
Rong-Men JIANG
;
Yan-Qiang CAO
;
Zhen-Yun MU
;
Yong ZHANG
Author Information
1. 河北医科大学
- Keywords:
Hepatitis C;
Hepativirus;
C,enotype;
Phylogeny
- From:
Chinese Journal of Experimental and Clinical Virology
2009;23(1):8-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate genotype of HCV infection among residents in a rural village, Hebei Province. Methods Blood samples of the 520 residents were collected, and C/E1 of HCV genome of the 483 samples were obtained by RT-PCR amplifying, and the gene sequences were analyzed and the polygenetic tree were drawn by the software Mega 4.0. Results In 483 subjects, HCV-RNA positive objectives are 70, positive prevalence is 14.5%, genotyping for all the samples successfully, including genotypes 1b and 2a, which are 36 (51.4%),34(48.6%) respectively. Conclusion HCV RNA positive rate is 14.5%, which is higher than general people. Subtypes 1b and 2a seemed to be the dominant genotypes of HCV in Zhao county area of Hebei Province.
