Analysis the relation of adults HBV vicinal failure and T cell subset, HLA-DR rang gene phenotype.
- Author:
Dan-Biao HU
1
;
Shi-Ke LIU
;
Li-Li ZHAO
;
Ai-Ping XU
;
Ying-Zhi HONG
;
Pin-Yuan CAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; HLA-DR Antigens; genetics; immunology; Hepatitis Antibodies; blood; Hepatitis B; genetics; immunology; prevention & control; virology; Hepatitis B Vaccines; administration & dosage; immunology; Hepatitis B virus; genetics; immunology; Humans; Phenotype; T-Lymphocyte Subsets; immunology
- From: Chinese Journal of Experimental and Clinical Virology 2009;23(1):17-19
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study and explore the relativity of adults HBV vicinal failure and HLA-DR, T cell subset, trace viruses infection. To accumulate date for formulating preventing adult HBV infection prophylactic-therapeutic measures.
METHODSSelect 20 adults randomly who had vaccinated with 10 microgYDV and produced anti-HBS successfully, and another 20 hadn't produced anti-HBs to form two groups-defeated group and contral group. Blood samples from two groups were taken for detecting the level of DR range gene phenotype: T cell subset, white blood cell HLA-DR, HLA-B27, HLA DRB1 * 07, DRB1* 04, DRB1 * 1001, DQB1 * 0401 and so on.
RESULTSThe level of CD4(-)/CD8(-) is lower in the infection group than in healthy group. But the average level of HLA-DR and HLA-B27 is higher in the infection group. The differences of HLA DRB1 * 07 gene frequency between two groups were significant (P <0.05), but the levels of CD3, CD4, CD8, CD7, CD4/CD8 and HLA DRB1 * 04, DRB1 * 1001, DQB1 * 0401 were not significant.
CONCLUSIONThe failure of HBV vaccination on adults may have relation to HLA-DR, HLA-B27, HLA DRB1 * 07, CD4(-)/CD8(-), etc.
