Analysis the relation of adults HBV vicinal failure and T cell subset, HLA-DR rang gene phenotype
10.3760/cma.j.issn.1003-9279.2009.01.007
- VernacularTitle:乙型肝炎疫苗免疫失败成人T细胞亚群、HLA-DR区基因表型分析
- Author:
Dan-Biao HU
1
;
Shi-Ke LIU
;
Li-Li ZHAO
;
Ai-Ping XU
;
Ying-Zhi HONG
;
Pin-Yuan CAO
Author Information
1. 浙江宁海县疾病预防控制中心
- Keywords:
Hepatitis B,Adult;
Hepatitis B vaccines;
HLA-D antigens;
T-Lymphocyte subsets;
DNA,recombinant;
Vaccines,synthetic
- From:
Chinese Journal of Experimental and Clinical Virology
2009;23(1):17-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study and explore the relativity of adults HBV vicinal failure and HLA-DR,T cell subset, trace viruses infection. To accumulate date for formulating preventing adult HBV infection prophylactic-therapeutic measures. Methods Select 20 adults randomly who had vaccinated with 10 μg YDV and produced anti-HBS successfully, and another 20 hadn't produced anti-HBs to form two groups-defeated group and contral group. Blood samples from two groups were taken for detecting the level of DR range gene phenotype: T cell subset, white blood cell HLA-DR, HLA-B27, HLA DRB1 * 07, DRB1 * 04, DRB1 * 1001, DQB1 * 0401 and so on. Results The level of CD4-/CD8- is lower in the infection group than in healthy group. But the average level of HLA-DR and HLA-B27 is higher in the infection group. The differences of HLA DRB1 * 07 gene frequency between two groups were significant ( P < 0.05), but the levels of CD3, CD4, CDS, CD7, CD4/CD8 and HLA DRB1 * 04, DRB1 * 1001, DQB1 * 0401 were not significant. Conclusion The failure of HBV vaccination on adults may have relation to HLA-DR, HLA-B27, HLA DRB1 * 07, CD4-/CD8- , etc.
