The role of serum leptin in infants with wheezing after respiratory syncytial virus infected
10.3760/cma.j.issn.1003-9279.2009.01.014
- VernacularTitle:呼吸道合胞病毒感染后婴幼儿喘息患者血清leptin水平的变化
- Author:
Zhuang-Gui CHEN
1
;
Ming LI
;
Jing-Zhi JI
;
Yong ZHANG
;
Hong CHEN
;
Yan-Feng CHEN
;
Fen-Hua CHEN
;
Li DENG
Author Information
1. 中山大学附属第三医院
- Keywords:
Leptin;
Respiratory syncytial viruses;
Asthma
- From:
Chinese Journal of Experimental and Clinical Virology
2009;23(1):38-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the role of serum leptin in infants with wheezing after respiratory syncytial virus infected. Methods 43 infants infected with RSV were given blood samples to detect leptin concentration with radioimmunoassays (RIA) within 24 hours after admission into hospital, discharged and 12 weeks later. Then, they were followed up for 2 years. 10 healthy children of the same age served as controls. Results 41.9% infants developed asthma after infected with RSV. Compared to control group, the serum level of leptin in the asthma group and non-asthma group were significantly higher before treatment ( t = 3.41 and 2.64 respectively, P < 0.05). When they were discharged, the serum level of leptin in the asthma group was significantly higher than that in non-asthma group and control group ( t = 5.74 and 6.23, respectively, P < 0.05). 12 weeks later, the serum level of leptin in the asthma group was still significantly higher than that in non-asthma group and control group ( t = 6.32 and 6.11, respectively, P < 0.05), but there were no difference between non-asthma group and control group ( t = 0.81, P > 0.05 ). Conclusion The serum level of leptin in infants with asthma after RSV infected was higher than that in healthy and non-asthma children. Persistent higher level of leptin may play an important role in infants with asthma after RSV infected.
