In vitro study on the effect of ribavirin reducing the EV71 replication.
- Author:
Yan ZHANG
1
;
Zhen ZHU
;
Shuang-Li ZHU
;
Hong-Qiu AN
;
Zhao-Hui YANG
;
Xue-Bin GUO
;
Wen-Bo XU
Author Information
- Publication Type:Journal Article
- MeSH: Cell Line; Enterovirus; drug effects; physiology; Enterovirus Infections; virology; Humans; Ribavirin; pharmacology; Virus Inactivation; drug effects; Virus Replication; drug effects
- From: Chinese Journal of Experimental and Clinical Virology 2009;23(1):44-46
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEObserve the effect of Ribavirin on reducing the EV71 replication, inactivating EV71 and protecting the RD-A cells against the EV71 infection in vitro.
METHODSUsing the EV71 isolated from Anhui Fuyang HFMD outbreak, the effect of Ribavirin on RD-A cells during the EV71 infection was observed.
RESULTSIn the experiment of Ribavirin inhibiting the EV71 replication, comparing with the no-Ribavirin-dealed virus control group, the group of 1:640 dilution of Ribavirin delayed the CPE for 2 days, while the normal cell group was growing very well. In the experiment of protecting cell from EV71 infection, comparing with the no-Ribavirin-dealed virus control group, the group of 1:8 dilution of Ribavirin delayed the CPE for 4 days. In the experiment of Ribavirin effect on the inactivation of EV71, the group of 1:40 dilution of Ribavirin delayed the CPE for 2 days comparing with the virus control group.
CONCLUSIONRibavirin could inhibit the replication of the EV71 and inactivate the EV71 in vitro. Additionally, Ribavirin could protect RD-A cells from EV 71 infection. The observation will contribute to EV71 infection control and quick medicine therapy.
