Detection of human papillomavirus in esophageal carcinoma tissues from Baoding City of Hebei Province

VernacularTitle:保定地区食管癌患者癌组织中人乳头瘤病毒感染的检测
Author: Xiao-Yu ZHAO ¹ ; Shu-Ying LI ; Ying LI ; Xiao-Li WANG ; Yu-Lan LI ; Xiao-Zhou WU ; Ling ZHOU ; Hong-Tu LIU ; Yi ZENG
Author Information

1. 河北大学
Keywords: Esophageal neoplasms; Carcinoma; Papillomavirus,human; Polymerase chain reaction
From: Chinese Journal of Experimental and Clinical Virology 2009;23(2):91-93
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between the human papillomavirus (HPV) and esophageal carcinoma in Baoding City of Hebei Province. Methods We detected HPV DNA in 42 formalin-fixed and paraffin-embedded tissues from surgically resected esophageal carcinomas from Baoding City of Hebei Province, by PCR with the general primer set of GP5 +/6 + for HPV L1 gene and type-specific primer sets for HPV16 and 18 as well. Results 37 from 42 esophageal carcinoma samples were HPV positive and the rate was 88.1% . Among the samples detected, 19 were HPV16 E6 positive and rate was 45.2%, eight were HPV18 E6 positive and rate was 19.0%. Conclusion The high rate of HPV in the esophageal carcinoma samples suggested that HPV plays an etiologic role in the development of esophageal cancer in Baoding City of Hebei Province.