Study on the immunogenicity of adeno-vector vaccine against H5N1 influenza A virus.
- Author:
Xiao-guang ZHANG
1
;
Kui-biao LI
;
Jing MA
;
Nai-fu WANG
;
Xiao-mei ZHANG
;
Yun-hu SANG
;
Jie DONG
;
Hong XU
;
Yi ZENG
Author Information
- Publication Type:Journal Article
- MeSH: Adenoviridae; genetics; immunology; Animals; Cell Line; Female; Genetic Vectors; genetics; immunology; Hemagglutinin Glycoproteins, Influenza Virus; administration & dosage; genetics; immunology; Humans; Influenza A Virus, H5N1 Subtype; genetics; immunology; Influenza Vaccines; administration & dosage; genetics; immunology; Influenza, Human; immunology; prevention & control; virology; Mice; Mice, Inbred BALB C; Random Allocation; Vaccination
- From: Chinese Journal of Experimental and Clinical Virology 2009;23(2):97-99
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo construct adenovirus vector vaccine against H5N1 influenza virus and study on the immunogenicity.
METHODSIn this study, we amplified hemagglutinin (HA) gene sequence of H5N1 influenza virus (A/Anhui/1/2005), then constructed an adenovirus vector vaccine (Adv-HA), followed by tests in BALB/c mice for the immunogenicity with the vaccine and immunization strategies.
RESULTSThe recombinate Adv-HA vaccine could effectively induce both humoral and cellular immunity against human H5N1 influenza virus.
CONCLUSIONThe Adv-HA vaccination against H5N1 influenza is a potential strategy and worthy of further investigation.
