Study on the immunogenicity of adeno-vector vaccine against H5N1 influenza A virus
10.3760/cma.j.issn.1003-9279.2009.02.007
- VernacularTitle:含H5N1-HA基因重组腺病毒疫苗的构建及其诱导免疫应答的初步探讨
- Author:
Xiaoguang ZHANG
1
;
KUIbiao LI
;
Jing MA
;
Naifu WANG
;
Xiaomei ZHANG
;
Yunhu SANG
;
Fie DONG
;
Hong XU
;
Yi ZENG
Author Information
1. 中国协和医科大学
- Keywords:
Influenza A virus,human;
Influenza A virus,avian;
Adenoviruses,human;
Genetic vecters;
Vaccines
- From:
Chinese Journal of Experimental and Clinical Virology
2009;23(2):97-99
- CountryChina
- Language:Chinese
-
Abstract:
Objective To construct adenovirus vector vaccine against H5N1 influenza virus and study on the immunogeuicity. Methods In this study, we amplified hemagglutinin (HA) gene sequence of H5N1 influenza virus (A/Anhui/1/2005), then constructed an adenovirus vector vaccine (Adv-HA), followed by tests in BALB/c mice for the immunogenicity with the vaccine and immunization strategies. Results The recombinate Adv-HA vaccine could effectively induce both humoral and cellular immunity against human H5N1 influenza virus. Conclusion The Adv-HA vaccination against H5N1 influenza is a potential strategy and worthy of further investigation.
