Seroepidemical study of Coxsackievirus A 16, in four provinces, China, 2005.
- Author:
Zhao-hui YANG
1
;
Shuang-li ZHU
;
Hui ZHU
;
Hong-qiu AN
;
Nai-ying MAO
;
Yi-xin JI
;
Xue-bin GUO
;
Shao-fu YIN
;
Zong-jiu ZHANG
;
Wen-bo XU
Author Information
- Publication Type:Journal Article
- MeSH: Antibodies, Viral; blood; China; epidemiology; Enterovirus A, Human; immunology; isolation & purification; Enterovirus Infections; epidemiology; immunology; Female; Humans; Infant; Male; Seroepidemiologic Studies
- From: Chinese Journal of Experimental and Clinical Virology 2009;23(2):103-105
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the situation of 1- 5-years-old children's antibody against Coxsackievirus A group 16 strain (CVA16) in Guangdong, Heilongjiang,Yunnan Province and Xinjiang Uygur Autonomous Regions, China, 2005, it can offer scientific evidences for preventing and controlling CVA16 causative hand-food and mouth disease.
METHODSUsing microneutrilization test, to study 503 serum samples randomly selected from sera collected in 2005.
RESULTSPositive rate of anti-CVA16 antibody were 41.90%, 9.40%, 40.00% and 34.40% in Guangdong, Heilongjiang,Yunnan and Xinjiang, respectively. Antibody titer was relative low (average, 1: 6.1) and there was no statistical difference of geometry mean of antibody titer (GMT) among Guangdong, Heilongjiang, Yunnan (F = 0.97, 0.40, 1.06, respectively; P > 0.05), while there had statistical difference of GMT between Heilongjiang and other three regions( F = 10.61, P < 0.00).
CONCLUSIONSThere had probably existed local epidemic in some regions of Guangdong, Heilongjiang, Yunnan Province and Xinjiang Uygur Autonomous Regions, China, 2005 or even before, but the area and degree of transmission and epidemic had difference. Children aged from 1- 5-years-old were relatively susceptible population of CVA16 infection.
