The level of TNF-alpha secretion of PBMC in patients with chronic hepatitis C and nonalcoholic fatty liver.
- Author:
Yi DONG
1
;
Hong-fei ZHANG
;
Shi-shu ZHU
;
Hao CHEN
;
Jing LI
;
Yun CHENG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Cells, Cultured; Child; Fatty Liver; metabolism; Female; Hepatitis C, Chronic; metabolism; Humans; Leukocytes, Mononuclear; metabolism; Male; Middle Aged; Tumor Necrosis Factor-alpha; metabolism; Young Adult
- From: Chinese Journal of Experimental and Clinical Virology 2009;23(2):109-111
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the roles of TNF-alpha secretion of PBMC in patients with chronic hepatitis C and Nonalcoholic fatty liver.
METHODSThe level of TNF-alpha secretion of PBMC in patients with chronic hepatitis C and Nonalcoholic fatty liver was detected by ELISA after culturing for 72 hours in vitro, as well as patients with chronic hepatitis C and the normal control.
RESULTS(1) Compared with the normal control, the level of TNF-alpha in group with chronic hepatitis C and in group with chronic hepatitis C and Nonalcoholic fatty liver notably increased. (2) Compared with the group with chronic hepatitis C, the level of TNF-alpha in group with chronic hepatitis C and Nonalcoholic fatty liver also notably increased.
CONCLUSIONIt suggested TNF-alpha takes important roles in the infection course of chronic hepatitis C with Nonalcoholic fatty liver.
