Significance of changes of T lymphocytes subsets in children with infectious mononucleosis and the effects of different interventions
10.3760/cma.j.issn.1003-9279.2009.02.114
- VernacularTitle:儿童传染性单核细胞增多症T细胞亚群的变化及其干预方法探讨
- Author:
Zhuang-Gui CHEN
1
;
Ming LI
;
Jing-Zhi JI
;
Hong CHEN
;
Yan-Feng CHEN
;
Fen-Hua CHEN
Author Information
1. 中山大学附属第三医院
- Keywords:
Infectious mononucleosis;
Herpesvirus 4,human;
T lymphocyte subsets;
Gmma-globulins;
Ganciclovir
- From:
Chinese Journal of Experimental and Clinical Virology
2009;23(2):118-120
- CountryChina
- Language:Chinese
-
Abstract:
objective To investigate changes of T lymphocytes subsets in children with infectious mononucleosis(IM) and the effects of different interventions.Methods Forty-eisht children with IM were Twenty healthy children from healthcare clinic serviced as control group.Results CD4(%),CD8(%)and the CD4,CD8 ratio in healthy control group were(34.12±3.53)%,(26.22±4.43)%and(1.41±0.3),in IVIG group were(24.2±4.3)%,(36.4±6.8)%and(0.72±0.12),and in GCV group were(23.7±5.1)%, (37.3±7.8)%and(0.67±0.13),respectively.CD4(%),CD8(%)and the ratio CD4/CD8 in the control grouD were significantly different from those in both groups with IM(P<0.05).Compared with pre-tratment levels.the 28 cases treated with IVIG had significant improvement,the CD4(%)increased,CD8(%)decreased and the ratio of CD4/CD8 increased after treatment(P<0.05).However,20 cases in GCV treatment group made less chunges(P>0.05).Meanwhile,the clinical symptoms and signs in the IVIG group were improved faster than that in the GCV group(P<0.05).The rate of remission in IVIG group was 88.7%vs.59.2%of GcV group(P<0.05);the hospital days in IVIG grouP were(9.2±4.3)days vs.(13.8±5.1)days in tlle GCV (P<0.05).Conclusion It is indicated that the subsets of T lymphocytes in periphend blood are obviously abnormal in children with IM caused by EBV infection in acute phase.WIG can regulate the immunological derangements of T lymphoeytes subsets,on which anti-viral therapy alone may have little impact.
