Pathological study of liver biopsy from 156 patients clinically diagnosed with mild chronic hepatitis B based on current guideline
10.3760/cma.j.issn.1003-9279.2009.02.021
- VernacularTitle:156例轻度慢性乙型肝炎患者肝组织病理学研究
- Author:
Lu-Biao CHEN
1
;
Hai-Hui HUANG
;
Xin SHU
;
Qi-Huan XU
;
Ni CHEN
;
Ka ZHANG
;
Gang LI
Author Information
1. 中山大学附属第三医院
- Keywords:
Hepatitis B,chronic;
Diagnosis;
Histological techniques
- From:
Chinese Journal of Experimental and Clinical Virology
2009;23(2):138-140
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the pathological features of liver tissues from patients clinically diagnosed with mild chronic hepatitis B based on current guideline and emphasize the important significance of liver puncture and biopsy for these patients. Methods Totally 156 patients clinically diagnosed with mild chronic hepatitis B based on current guideline received liver puncture under the real-time Doppler ultrasonographic guiding. Pathological diagnosis was made after microscopic examinations of the liver tissue specimens stained with hematoxylin-eosin (HE) and reticular fiber staining. The differences between clinical and pathological diagnosis for these patients were analyzed. Results Finally, 105 (67.3%) patients were pathologically diagnosed with mild chroniehepatitis B; 28 (18.0%), 3 (1.9%) and 20 (12.8%) patients were pathologically diagnosed as moderate, severe chronic hepatitis B and cirrhosis, respectively. Forty-eight (30.8%) and 39 (25.0%) patients of non-mild chronic hepatitis B were found to have G3-4 inflammation and S3-4 fibrosis, respectively. Differences in serum alanine aminotransferase, aspartate aminotransferase, total bilirubin or albumin between mild and non-mild chronic hepatitis B based on pathological diagnosis were not statistically significant (t-test, P > 0.05 ). Comclusions Accurate pathological diagnosis is helpful to guiding an antiviral therapy.
