Molecular epidemiology of rotavirus among children under 5 years old hospitalized for diarrhea in China.
- Author:
Su-Hu YANG
1
;
Hong WANG
;
Na LIU
;
Qing ZHANG
;
Shu-Xian CUI
;
Dan-Di LI
;
Miao JIN
;
Qing CHEN
;
Zhao-Jun DUAN
Author Information
- Publication Type:Journal Article
- MeSH: Child, Hospitalized; Child, Preschool; China; epidemiology; Diarrhea; epidemiology; therapy; virology; Feces; virology; Female; Humans; Infant; Male; Molecular Epidemiology; Molecular Sequence Data; Rotavirus; classification; genetics; isolation & purification; Rotavirus Infections; epidemiology; therapy; virology; Seasons
- From: Chinese Journal of Experimental and Clinical Virology 2009;23(3):168-170
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study molecular epidemiology of Rotavirus among children under 5 years of age in china.
METHODSStool specimens were collected from 4047 inpatients under 5 years of age with diarrhea in our 9 hospital-based surveillance sites from January 2006 to December 2007 following the WHO Rotavirus surveillance protocol. Rotavirus were detected by ELISA, Further strain characterization of rotavirus was carried out with RT-PCR.
RESULTSA total of 4047 stool samples were collected and 3862 of total stools were tested among which 1700 was positive. The Rotavirus positive rate is 44.0%. A peak admission of rotavirus diarrhea was observed from November to next January. More than 95.4% of viral diarrhea patients occurred in their first 2 years. The incidence rates of rotavirus diarrhea were highest in 12-17 months of age. The most common rotavirus strain was P[8]G3(58.3%); followed by P[8] G1(22.1%), P[4]G1 (3.0%), P[8]G9 (2.4%). G4 was not detected in this study. The four common strains were 80.8% in the world.
CONCLUSIONRotavirus diarrhea was an important infectious disease among children under 5 years of age in China. Safe and effective rotavirus vaccines for the prevention of rotavirus diarrhea and reduction of treatment costs are of significant importance to China.
