Molecular epidemiology of rotavirus among children under 5 years old hospitalized for diarrhea in China
10.3760/cma.j.issn.1003-9279.2009.03.003
- VernacularTitle:2006-2007年我国五岁以下住院儿童轮状病毒流行病学研究
- Author:
Su-Hua YANG
1
;
Hong WANG
;
Na LIU
;
Qing ZHANG
;
Shu-Xian CUI
;
Dan-Di LI
;
Miao JIN
;
Qing CHEN
;
Zhao-Jun DUAN
Author Information
1. 南方医科大学
- Keywords:
Rotavirus;
Diarrhea;
Immunologic survieUance
- From:
Chinese Journal of Experimental and Clinical Virology
2009;23(3):168-170
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study molecular epidemiology of Rotavims among children under 5 years of age in china. Methods Stool specimens were collected from 4047 inpatients under 5 years of age with diarrhea in our 9 hospital-based surveillance sites from January 2006 to December 2007 following the WHO Rotavirus surveillance protocol. Rotavirus were detected by ELISA, Further strain characterization of rotavirus was carried out with RT-PCR. Results A total of 4047 stool samples were collected and 3862 of total stools were tested among which 1700 was positive. The Rotavims positive rate is 44.0%. A peak admission of rotavirus diarrhea was observed from November to next January. More than 95.4% of viral diarrhea patients occurred in their first 2 years. The incidence rates of rotavirus diarrhea were highest in 12--17 months of age. The most common rotaviras strain was P[8]G3(58.3%) ; followed by P[8]G1 (22.1%), P[4]G1 (3.0%), P[S]G9 (2.4%). G4 was not detected in this study. The four common strains were 80.8% in the world. Conclusion Rotavirus diarrhea was an important infectious disease among children under 5 years of age in China. Safe and effective rotavirus vaccines for the prevention of rotavirus diarrhea and reduction of treatment costs are of significant importance to China.
