Study on rhGM-CSF as adjuvant in revaccination among adults of non-and hyporesponders to hepatitis B vaccine.
- Author:
He-Xiang CHEN
1
;
Xiang-Yang WANG
;
Shun-Qin WANG
;
Hong-Tao HE
;
Xiao-Guang LUO
;
Xiao-Gang CHEN
;
Chao-Shuang LIN
Author Information
- Publication Type:Journal Article
- MeSH: Adjuvants, Immunologic; administration & dosage; Adolescent; Adult; Data Collection; Female; Granulocyte-Macrophage Colony-Stimulating Factor; administration & dosage; immunology; Hepatitis B; blood; immunology; prevention & control; Hepatitis B Antibodies; blood; immunology; Hepatitis B Vaccines; administration & dosage; immunology; Humans; Immunization Schedule; Immunization, Secondary; Male; Middle Aged; Recombinant Proteins; Young Adult
- From: Chinese Journal of Experimental and Clinical Virology 2009;23(3):177-179
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of recombinant human granulocyte macrophage colony stimulating factor (rhGM-CSF) as adjuvant on immune response in adults of non-and hyporesponders to hepatitis B vaccine.
METHODSThose who were once immunized with recombined yeast gene hepatitis B vaccine more than one standard scheme in two years and negative for hepatitis B markers were randomly sorted as group A and group B. 33 adults of group A were given hepatitis B vaccine 10 microg each time. The immune procedure was 0, 1 and 6 month. 34 adults of group B were given rhGM-CSF 300 microg for the first day, then 10 microg each time for routine immune. The blood samples were collected before the first injection and in 1, 2 and 8 months (T1, T2, T8) following the first injection to test Anti-HBs.
RESULTSAnti-HBs positive conversion rates of group A and B at T8 was 39.39% and 64.71% respectively (P = 0.038). Anti-HBs levels of group B at T1, T2, T8 were (113.85 +/- 198.56) mIU/ml, (312.40 +/- 349.44) mIU/ml, (427.74 +/- 411.58) mIU/ml (P = 0.001). There was significant difference between group A and B in T8 Anti-HBs levels (P = 0.010).
CONCLUSIONBetter immune response was found in the group of rhGM-CSF with hepatitis B vaccine. So rhGM-CSF can induce the immune respond to hepatitis B vaccine.
