Clinical analysis of 12 patients with angioimmunoblastic T cell lymphoma.
- Author:
Shu-Hong WANG
1
;
Quan-Shun WANG
;
Lu SUN
;
Hong-Hua LI
;
Yu ZHAO
;
Bo-Jun JIA
;
Xiao-Ling ZHANG
;
Li YU
Author Information
1. Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
- Publication Type:Journal Article
- MeSH:
Aged;
Female;
Humans;
Immunoblastic Lymphadenopathy;
diagnosis;
pathology;
therapy;
Lymph Nodes;
pathology;
Lymphoma, T-Cell, Peripheral;
diagnosis;
pathology;
therapy;
Male;
Middle Aged;
Survival Rate
- From:
Journal of Experimental Hematology
2010;18(5):1208-1210
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the clinical, pathological characters and prognosis of patients with angioimmunoblastic T cell lymphoma (AITL), the clinicopathologic features, immunophenotypes, therapy and survival rate of 12 AITL patients which were confirmed by pathologic examination were retrospectively studied. The results indicated that main symptom was observed as general lymphadenopathy, however, 9 patients had fever. The diagnosis of AITL was based on lymph-node biopsy. The histopathologic characteristics of AITL showed the damage of normal lymphnode structure, the proliferation of immunoblastic cells and arborescent super vascularization. All immunophenotypes were mature peripheral T-cellular. CVP regimen was the most common chemotherapy regimen used for patients. 58% patients have a good initial response to chemotherapy. 3-year survival was 25%, with median survival time of 25 months. In conclusion, most cases of AITL display an aggressive course, therefore, the disease progresses rapidly and has unfavorable prognosis, further studies are required to improve its therapy regimen.
