Alteration of methylation status of death-associated protein kinase (dapk) gene promoter in patients with acute myeloid leukemia.
- Author:
Jun QIAN
1
;
Dong-Ming YAO
;
Jiang LIN
;
Qin CHEN
;
Yun LI
;
Run-Bi JI
;
Jing YANG
;
Zhen QIAN
;
Gao-Fei XIAO
;
Ya-Li WANG
Author Information
1. Department of Hematology, Jiangsu University Affiliated People Hospital, Zhenjiang 212002, Jiangsu Province, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Apoptosis Regulatory Proteins;
genetics;
Calcium-Calmodulin-Dependent Protein Kinases;
genetics;
Child;
Child, Preschool;
DNA Methylation;
Death-Associated Protein Kinases;
Female;
Humans;
Leukemia, Myeloid, Acute;
genetics;
Male;
Middle Aged;
Promoter Regions, Genetic;
Young Adult
- From:
Journal of Experimental Hematology
2010;18(6):1390-1394
- CountryChina
- Language:Chinese
-
Abstract:
This study was purposed to analyze the methylation status of death-associated protein kinase (dapk) gene promoter in Chinese patients with acute myeloid leukemia (AML) and its relationship with clinical features. The methylation-specific PCR (MSP) technique was used to detect dapk promoter methylation in bone marrow samples from 112 cases of AML. The results indicated that gene dapk promoter hypermethylation was detected in 82 cases (73.2%), but not in 13 control group. There was no correlation of dapk gene hypermethylation with sex, age, WBC counts, platelet counts, hematologic parameters, chromosomal abnormalities and different subtypes of AML patients. It is concluded that dapk gene hypermethylation may be a common molecular event in AML.
