Research progress on second-hit in malignant lymphomagenesis-- review.
- Author:
Xiao-Yang LI
1
;
Jun-Min LI
Author Information
1. Department of Hematology, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Leukemia;
etiology;
Lymphoma;
etiology;
Mutation;
Neoplastic Stem Cells;
cytology
- From:
Journal of Experimental Hematology
2010;18(6):1627-1631
- CountryChina
- Language:Chinese
-
Abstract:
Stem/progenitor cells contribute to normal development of organs, but their mutation may lead to many human diseases including cancer. Stem/progenitor cells and some of the cancer cells have the same abilities of self-renewal and differentiation, suggesting that tumors were initiated from mutated stem/progenitor cells, the cancer stem/progenitor cells. The recent studies on the origin of the non-Hodgkin's lymphomas has proved that the second-hit aggravates gene mutation in lymphocytic progenitor cells, leading to the generation of lymphoma. This review summarizes the current advances in the studies of the second-hit at stem/progenitor cells in oncogenesis of B-cell non-Hodgkin's lymphoma.
