Multidrug resistance of tumor/progenitor stem cells-- review.
- Author:
Lei WANG
1
;
Bao-An CHEN
Author Information
1. Department of Hematology, Southeast University Medical College, Nanjing 210009, Jiangsu Province, China.
- Publication Type:Journal Article
- MeSH:
Cell Line, Tumor;
Drug Resistance, Multiple;
Drug Resistance, Neoplasm;
Humans;
Neoplasms;
drug therapy;
Neoplastic Stem Cells;
drug effects;
Stem Cells;
drug effects
- From:
Journal of Experimental Hematology
2010;18(6):1644-1648
- CountryChina
- Language:Chinese
-
Abstract:
Tumor Stem/Progenitor Cells are characterized by undifferentiation/hypodifferention, self-renewal, differentiation potential, which is responsible for tumor occurrence, growth and metastasis. The theory about tumor stem/progenitor cells provides a new insight to recognize the origin and essence of tumors. Gaining a better insight into the origin of tumor stem/progenitor cells and the mechanisms of tumor stem/progenitor cells resistance to chemotherapy may lead to new therapeutic targets and better anticancer strategies. This review summarizes recent progress of research on the origin of tumor stem/progenitor cells and multidrug resistance.
