Changes of plasma cytokines in patients with severe hepatitis treated with a probiotic preparation.
- Author:
Ming-qin LU
1
;
Yu ZHENG
;
Yong-ping CHEN
;
Ji LI
;
Hao-hao YE
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Cytokines; blood; Female; Hepatitis; blood; therapy; Humans; Interleukin-10; blood; Interleukin-2; blood; Interleukin-6; blood; Male; Middle Aged; Probiotics; therapeutic use; Tumor Necrosis Factor-alpha; blood; Young Adult
- From: Chinese Journal of Hepatology 2008;16(4):283-285
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the changes of plasma cytokines in patients with severe hepatitis treated with a probiotic preparation.
METHODSOne hundred twelve patients with severe hepatitis treated with a basic regimen were randomly divided into a probiotic preparation treatment group and a control group. Their plasma cytokines such as tumor necrosis factor alpha, interleukin-2, interleukin-6, interleukin-10, were determined by conventional techniques.
RESULTSClinical symptoms of 84.5% of the treatment group were obviously improved. The treatment effectiveness in this group was better than that in the control group (X2=8.888). It showed that liver functions were significantly improved compared to those of the control group . After the probiotic preparation therapy, there were significant decreases in the concentrations of TNFa and IL-6. TNFa and IL-6 in the treatment group and in the control group were (109.4+/-14.7) pg/ml vs (128.7+/-18.8) pg/ml and (84.3+/-20.1) pg/ml vs (109.1+/-18.7) pg/ml respectively. However, the concentrations of IL-10 and IL-2 in the treatment group increased obviously: IL-2 was (59.8+/-12.2) pg/ml vs (47.1+/-6.7) pg/ml and IL-10 was (30.6+/-6.6) pg/ml vs (22.5+/-6.1) pg/ml.
CONCLUSIONThe probiotic preparation treatment effectively reduces the TNFa and IL-6 and increases the concentrations of IL-10 and IL-2 in the blood of the patients with severe hepatitis.
