Chemical Dissolution of Intrahepatic Stones in Vitro.
10.3348/jkrs.1995.33.6.945
- Author:
Young Goo KIM
;
Kun Sang KIM
;
Jong Beum LEE
;
Hyung Jin SHIM
;
Sang Shin JOO
;
Kyung H LEE
;
Byung Gook KWAK
;
Su Kyoung CHAE
;
Hymn Mee PARK
- Publication Type:In Vitro ; Original Article
- MeSH:
Acetylcysteine;
Edetic Acid;
Humans;
Hydrogen-Ion Concentration;
Urea;
Weight Loss
- From:Journal of the Korean Radiological Society
1995;33(6):945-948
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The in vitro dissolution of intrahepatic stones was evaluated using the various solvent mixtures. MATERIALS AND METHODS: Sixty four intrahepatic stones from 16 patients were used. Four kinds of solvent mixtures(No. 1 = basic buffer + EDTA, No. 2=1 + Sulfobetain-12, No. 3=2 + N-acetylcysteine, No. 4=3 + urea) were used. Dissolution rates were determined by measuring the weight loss of stones after 6, 12, 24, 48 hours incubation periods, respectively. RESULTS: The highest dissolution rates in dissolving intrahepatic stones were achieved with No. 4 solvent mixture(1% W/V EDTA/80mM, Sulfobetain-12/1 M, urea, pH 9.5). CONCLUSION: lntrahepatic stones could be largely dissolved up to about 70% of their initial weight after 48 hours incubation period in vitro.
