Adefovir dipivoxil treatment of hepatic cirrhosis complicated with hepatitis B virus associated glomerulonephritis.
- Author:
Dong-fu LI
1
;
Zhen-jing JIN
;
Yong-sheng CHEN
;
Lian-ming QIAO
;
Jian ZHOU
Author Information
- Publication Type:Clinical Trial
- MeSH: Adenine; analogs & derivatives; therapeutic use; Adolescent; Adult; Antiviral Agents; therapeutic use; Female; Glomerulonephritis; complications; drug therapy; virology; Hepatitis B; complications; drug therapy; Hepatitis B virus; Humans; Liver Cirrhosis; complications; drug therapy; virology; Male; Middle Aged; Organophosphonates; therapeutic use; Young Adult
- From: Chinese Journal of Hepatology 2008;16(5):349-351
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the efficacy and safety of adefovir dipivoxil (ADV) in treating hepatic cirrhosis complicated with hepatitis B virus associated glomerulonephritis.
METHODSSix hepatic cirrhosis (Child-Pugh A grade, liver function compensated) patients complicated with hepatitis B virus associated glomerulonephritis diagnosed by renal biopsy, real time PCR and urinary protein tests were treated with ADV for one year in addition to a routine treatment. The dosage of ADV was 100mg daily.
RESULTSAfter 3 and 6 months treatment the negative conversion rates of HBV-DNA were 33.3% and 83.3%; the negative conversion rates of HBeAg were 16.7% and 66.7%; the positive conversion rates of HBeAb were both 16.7%; the recovery rates of ALT were 83.3% and 100.0%; and the recovery rates of TBil were 66.7% and 83.3% respectively. Protein in the urine of two patients was decreased to 0.3 g/d and in three patients it was 50% of the original values. After 1 year treatment the disease subsided fully in 3 and partially in 2 patients.
CONCLUSIONTreating hepatic cirrhosis complicated with hepatitis B virus associated glomerulonephritis using adefovir dipivoxil is effective and safe.
