Comparison of antiviral responses to adefovir dipivoxil therapy of genotype B and genotype C HBV infected patients.
- Author:
Ai-zhong ZENG
1
;
Hui DENG
;
Feng-ying PENG
;
Xiao-juan XIN
;
Chun YANG
;
Qing-ling LI
;
Jin-jun GUO
;
Zhen-zhen ZHANG
;
Mei-jun HAO
;
Zhe YUAN
;
Wen-xiang HUANG
;
Ai-long HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Adenine; analogs & derivatives; pharmacology; therapeutic use; Adolescent; Adult; Aged; Antiviral Agents; pharmacology; therapeutic use; DNA, Viral; Female; Genotype; Hepatitis B virus; drug effects; genetics; Hepatitis B, Chronic; drug therapy; virology; Humans; Male; Middle Aged; Organophosphonates; pharmacology; therapeutic use; Treatment Outcome; Young Adult
- From: Chinese Journal of Hepatology 2008;16(6):412-415
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the role of HBV genotypes on their response to adefovir dipivoxil (ADV) antiviral therapy.
METHODSHBV genotypes from 177 HBeAg-positive chronic hepatitis B (CHB) patients were identified and the patients were treated with ADV 10 mg per day for 48 weeks. The clinical data in terms of serum HBV DNA seroclearance, mean HBV DNA reduction (log value), HBeAg loss, anti-HBe seroconversion and serum ALT of those patients were analyzed against their HBV genotypes.
RESULTSGenotype B and genotype C were found in 102 and 65 cases, respectively. The mean HBV DNA reduction in patients with genotype B and genotype C at their treatment times of 12, 24 and 48 weeks was 2.2 log10copies/ml, 2.1 log10copies/ml (P more than 0.05), 2.7 log10copies/ml, 2.4 log10copies/ml (P more than 0.05) and 3.6 log10copies/ml, 3.1 log10copies/ml (P less than 0.05), respectively. At the end of the therapy (48 weeks), 43 (42.2%) patients with genotype B HBV infection and 22 (33.8%) patients with genotype C HBV infection had achieved HBV DNA seroclearance (P less than 0.05).
CONCLUSIONSOur results suggest that genotype B HBV has a better virological response to ADV therapy in HBeAg-positive chronic hepatitis B patients than that of genotype C. Longer terms of ADV treatment are needed to confirm this conclusion.
