Karyotype analysis of 283 cases of myelodysplastic syndrome.
- Author:
Han-zhang PAN
1
;
Zhi-mei CHEN
;
Ji-yu LOU
;
Wei-lai XU
;
Ji JIN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human, Pair 8; genetics; Female; Humans; Karyotyping; Male; Middle Aged; Myelodysplastic Syndromes; genetics; Prognosis; Translocation, Genetic; genetics
- From: Journal of Zhejiang University. Medical sciences 2006;35(2):143-146
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the implication of karyotype analysis in diagnosis and prognosis of myelodysplastic syndrome (MDS).
METHODSThe chromosomes were prepared with direct method, brief culture of cells and R-banding techniques, and then the karyotypic analysis was performed.
RESULTSeventy-seven out of 283 patients (27.21%) had karyotypic abnormalities, including the numeral abnormalities of chromosomes and structural alterations. The most common chromosomal aberrations were +8, -20/20q-, -Y, translocation, -7/7q-, +9, -5/5q-. The rate of abnormal karyotype in refractory anemia with erythroblasts (RAEB) and refractory anemia erythroblasts-transformation (RAEB-t) was much higher than in refractory anemia (RA). Patients with abnormal karyotype or higher IPSS scores had a higher risk of transformation into acute leukemia than patients with normal karyotype or lower IPSS scores (P<0.05).
CONCLUSIONMDS is a highly heterogenous disorder and karyotype analysis is helpful for its diagnosis and prognosis estimation.
