Vascular endothelial growth factor and pigment epithelium-derived factor in aqueous humor of patients with choroidal neovascularization.
- Author:
Jian-ping TONG
1
;
Ye SHEN
;
Wai-man CHAN
;
Shun-chao LIN
;
Zhi-pei PENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Aqueous Humor; chemistry; Choroidal Neovascularization; metabolism; Eye Proteins; analysis; Female; Humans; Male; Middle Aged; Nerve Growth Factors; analysis; Serpins; analysis; Vascular Endothelial Growth Factor A; analysis
- From: Journal of Zhejiang University. Medical sciences 2006;35(3):311-314
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the levels of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) in aqueous humor of patients with active choroidal neovascularization (CNV).
METHODSAqueous humor samples were obtained from 32 patients with active CNV. The concentrations of VEGF and PEDF in aqueous humor were measured by enzyme linked immunosorbent assay (ELISA) for quantitative analysis. VEGF and PEDF in 10 samples of aqueous humor from patients with cataract were also detected by the same methods as control.
RESULTThe mean VEGF and PEDF concentrations in aqueous humor of active CNV patients were higher than those in the control group (P=0.000).
CONCLUSIONThe patients with active CNV exhibit significantly higher VEGF and PEDF levels than those in control, indicating that VEGF along with PEDF may modulate the formation of CNV.
