Expression of RhoC protein in human primary hepatocellular carcinoma and its clinical significance.
- Author:
Xiu-jun CAI
1
;
Guan-gen XU
;
Bo SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Carcinoma, Hepatocellular; metabolism; pathology; Female; Humans; Liver Neoplasms; metabolism; pathology; Male; Neoplasm Invasiveness; Neoplasm Metastasis; Prognosis; rho GTP-Binding Proteins; biosynthesis; genetics; rhoC GTP-Binding Protein
- From: Journal of Zhejiang University. Medical sciences 2006;35(4):394-396
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the expression of RhoC protein in human primary hepatocellular carcinoma (HCC) and pericancerous liver (PCL) tissues and its relation to HCC prognosis.
METHODSImmunohistochemical method was used to detect the expression of RhoC protein in HCC, PCL of 43 patients. Thirty-six patients were followed up after they received radical resection.
RESULTThe expression of RhoC protein in HCC was significantly higher than that in PCL. Rhoc expression was increased in cases with poor differentiation, portal vascular invasion, unintact envelope and multiple masses. The survival analysis showed that HCC with lower RhoC protein expression had better clinical outcomes.
CONCLUSIONRhoC protein expression is correlated with infiltration and metastasis in HCC. RhoC protein can be used as a prognostic indicator for HCC.
