Effect of chronic transauricular kindled seizures on passive-avoidance test memory retention in rats.
- Author:
Qing LI
1
;
Lu-ying LIU
;
Yuan-yuan ZHU
;
Wen-xia ZHOU
;
Zhong CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Avoidance Learning; Hippocampus; metabolism; pathology; physiopathology; Histamine; metabolism; Kindling, Neurologic; Male; Memory Disorders; etiology; physiopathology; Rats; Rats, Sprague-Dawley; Seizures; metabolism; pathology; physiopathology; gamma-Aminobutyric Acid; metabolism
- From: Journal of Zhejiang University. Medical sciences 2006;35(4):419-423
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate effect of chronic transauricular kindled seizures on passive-avoidance test memory retention in rats.
METHODSChronic transauricular kindled seizures was induced by repeated application of initially subconvulsive electrical stimulation through ear-clip electrodes once every 24 h until the occurrence of 3 consecutive clonic-tonic seizures. A passive avoidance test was used to measure memory retention ability. Morphological changes in neurons of hippocampal CA1 region was examined after HE staining. Histamine, gamma-aminobutyric acid (GABA) and glutamate levels in the hippocampus were measured by high performance liquid chromatography (HPLC).
RESULTChronic transauricular kindled seizures impaired passive-avoidance test memory retention in rats. The damaged CA1 neurons were observed and histamine content in the hippocampus markedly decreased 24 h after the end of kindling in the chronic transauricular kindled rats.
CONCLUSIONChronic transauricular kindled seizure impaired passive-avoidance test memory retention, and it might be due to the damaged CA1 neurons and a decrease of histamine in the hippocampus induced by epilepsy.
