Experimental treatment of chronic pelvic inflammatory disease in rats with acupoint injection of Astragalus parenteral solution.
- Author:
Xue-feng CAI
1
;
Zhang-lian WANG
;
Li-fang CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Acupuncture Points; Animals; Astragalus membranaceus; chemistry; Chronic Disease; Drugs, Chinese Herbal; administration & dosage; Female; Injections; Pelvic Inflammatory Disease; drug therapy; Phytotherapy; Rats; Rats, Wistar
- From: Journal of Zhejiang University. Medical sciences 2006;35(4):430-439
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of acupoint injection with astragalus parenteral solution in rat chronic pelvic inflammatory disease (CPID).
METHODSFifty female Wistar rats were randomly divided into 6 groups: CPID model was induced in 4 groups, in addition to control group and false surgery group. The rats were given acupoint (Guanyuan and Zusanli) injection with astragalus parenteral solution and saline. The drug group was fed with Qianjinpian solutions. The histopathologic changes of uterus were observed and serum IL-2 and TNF-alpha levels detected.
RESULTThe rats in the model group showed chronic inflammatory changes, the animals in astragalus parenteral injection group and Qianjinpian group showed little histopathological changes. The serum TNF-alpha levels in the model group were significantly higher than those in the normal group and the astragalus parenteral injection group; while the IL-2 levels in model group were significantly lower than those of other 5 groups. The TNF-alpha and IL-2 levels in astragalus parenteral injection group were similar to those of normal group.
CONCLUSIONThe treatment of chronic pelvic inflammatory disease with acupoint injection of astragalus parenteral solution might be effective.
