Expression of c-fos, OPG, OPGL in rabbit mandibular distraction osteogenesis zone.
- Author:
Wei-li GE
1
;
Zhi-jian XIE
;
Jian-feng HE
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Mandible; cytology; metabolism; Osteocytes; metabolism; Osteogenesis, Distraction; Osteoprotegerin; biosynthesis; genetics; Proto-Oncogene Proteins c-fos; biosynthesis; genetics; RANK Ligand; biosynthesis; genetics; Rabbits; Random Allocation
- From: Journal of Zhejiang University. Medical sciences 2006;35(5):496-500
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the possible signal transduction mechanism of the mechanical stress induced by the distraction procedure in osteocytes.
METHODSAn animal model of mandibular distraction osteogenesis in rabbits was established. The expressions of c-fos, OPG and OPGL were detected by ultrasensitive S-P immunohistochemical method.
RESULTAt 4 and 8 days after distraction, distraction zone showed strong positive staining of c-fos, which were apparently higher than that in distraction zone of 2, 4 and 6 weeks after consolidation. At 4 and 8 days after distraction and 2 weeks after consolidation, the expression of OPG was strong, and then wore off gradually at 4 and 6 weeks after consolidation. Weak signals of OPGL could be detected at 6 weeks after consolidation only.
CONCLUSIONc-fos, OPG and OPGL are important regulators in distraction osteogenesis. c-fos is interrelated with the mechanical stress induced by the distraction procedure closely, OPG promotes new bone formation, while OPGL plays a more active role in bone remodeling.
