Assessment on effects of tongjiang granule on experimental reflux esophagitis in rats.
- Author:
Xu-dong TANG
1
;
Hong-mei WU
;
Zhi-bin WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Drugs, Chinese Herbal; therapeutic use; Esophagitis, Peptic; drug therapy; pathology; Esophagus; drug effects; pathology; Female; Male; Phytotherapy; Powders; Random Allocation; Rats; Rats, Sprague-Dawley
- From: Chinese Journal of Integrated Traditional and Western Medicine 2006;26(9):818-821
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of tongjiang granule (TJG) on reflux esophagitis (RE) in rats.
METHODSTwo rat models of RE were established respectively by cardioplasty + pyloric ligation + Roux-en-Y gastro-jejunum anastomosis and by placed a fixed steel ring into the gastric cardia, and the model rats were treated with various dosages of TJG or cisapride by gastric perfusion.
RESULTSRat models were established successfully by both methods. The score of pathological changes of esophagus mucosa in the model rats, made by either method, after high-dosage TJG treatment was lower than that in the model rats (P < 0.05), but equal to that in the cisapride treated model rats. High and moderate dosages of TJG were shown by transmission electron microscope to have effects of alleviating heckle cells and inflammatory reaction. They could reduce the level of gastric acid, more significant in high and moderate dosage groups (P < 0.05), while cisapride couldn't.
CONCLUSIONTJG is effective in treating experimental RE in rats to a certain extent.
