Regulatory effects of yiqi zishen granule on helper T-lymphocyte subsets in IgA nephropathy patients.
- Author:
Da-jun YU
1
;
Li-fang NIE
;
Yong-gang XU
Author Information
- Publication Type:Clinical Trial
- MeSH: Adult; Drugs, Chinese Herbal; therapeutic use; Female; Glomerulonephritis, IGA; drug therapy; immunology; Humans; Interferon-gamma; blood; Interleukin-10; blood; Male; Phytotherapy; Powders; T-Lymphocytes, Helper-Inducer; drug effects
- From: Chinese Journal of Integrated Traditional and Western Medicine 2006;26(9):836-838
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the pathogenesis of IgA nephropathy (IgAN) and the effect of Yiqi Zishen Granule (YZG) on the helper T-lymphocyte subsets Th1/Th2 in IgAN patients.
METHODSIntracellular cytokines secreted by Th1/Th2 were measured using flow cytometry in 24 healthy subjects and 31 IgAN patients treated by YZG before and after treatment.
RESULTSLevel of interferon-gamma (IFN-gamma) was lower (P < 0.05) and levels of interleukin 4 (IL-4) and interleukin 10 (IL-10) were higher (P < 0.01) in the IgAN patients than those in the healthy controls, showing imbalance of Th1/Th2 in the IgAN patients. After YZG treatment, the level of IFN-gamma increased and IL-10 level decreased (P < 0.01).
CONCLUSIONImbalance of Th1/Th2 exists in IgAN patients. YZG has a regulatory effect on imbalance of Th1/Th2 in IgAN patients.
