Effects of modified longdan xiegan decoction on hyperandrogenism in patients with polycystic ovary syndrome of stagnant fire in Gan channel type.
- Author:
Li-li TAO
1
;
Yu-zhen ZHANG
;
Xia SANG
Author Information
- Publication Type:Clinical Trial
- MeSH: Adolescent; Adult; Drugs, Chinese Herbal; therapeutic use; Female; Humans; Hyperandrogenism; drug therapy; etiology; Medicine, Chinese Traditional; Phytotherapy; Polycystic Ovary Syndrome; complications; drug therapy
- From: Chinese Journal of Integrated Traditional and Western Medicine 2006;26(9):838-841
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the therapeutic effect of modified Longdan Xiegan Decoction (LXD) on hyperandrogenism in patients with polycystic ovary syndrome (POS) of stagnant fire in Gan channel type.
METHODSForty-eight patients were divided into two groups: the LXD group (25 cases) treated with LXI) for 3 months, and the Diane-35 group (23 cases) with Diane-35. Condition of menstruation, acne, hairiness were observed, basal body temperature (BBT) was measured, and the serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), free testosterone (FT), and androstenedione (A) were detected before and after 3 months' treatment. Meanwhile, adverse reaction was observed.
RESULTSAfter treatment, the condition of menstrual disorder, acne and single-phase BBT were improved significantly, and serum levels of LH, LH/FSH, FT and A decreased in both groups (P < 0.05), showed insignificant difference between them (P > 0.05). The PRL level dropped in the LXD group (P < 0.05), which significantly lower than that in the Diane-35 group (P < 0.05). There were 3 cases with adverse reaction of irregular colporrhagia and 5 cases with nausea and vomiting in the Diane-35 group, while no adverse reaction in the LXD group occurred.
CONCLUSIONModified LXD could significantly improve the condition in hyperandrogenism patients with POS of stagnant fire in Gan channel type.