Effect of fulu baoxin oral liquid on lipid peroxidation, plasma nitric oxide and vascular endothelial growth factor in acute myocardial infarction rats.
- Author:
Jing HUANG
1
;
Yong-sheng HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Oral; Animals; Drugs, Chinese Herbal; administration & dosage; therapeutic use; Lipid Peroxidation; drug effects; Male; Myocardial Infarction; blood; drug therapy; metabolism; Myocardium; metabolism; Nitric Oxide; blood; Phytotherapy; Rats; Rats, Wistar; Superoxide Dismutase; metabolism; Vascular Endothelial Growth Factor A; metabolism
- From: Chinese Journal of Integrated Traditional and Western Medicine 2006;26(10):926-929
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect and mechanism of Fulu Baoxin Oral Liquid (FBOL) on lipid peroxidation (LPO), plasma nitric oxide (NO) and vascular endothelial growth factor (VEGF) in myocadial tissue of rats with acute myocardial infarction (AMI).
METHODSThe contents of superoxide dismutase (SOD), malondialdehyde (MDA) and VEGF in myocardial tissue and the plasm NO level were determined by immunohistochemical method.
RESULTSCompared with those in AMI model rats, contents of SOD, plasma NO and myocardial VEGF were higher and MDA was lower obviously in the FBOL high dosage and coronary favorable medicine treated rats (P < 0.05 or P < 0.01).
CONCLUSIONFBOL could increase SOD activity and lower MDA content in myocardial tissue, and up-regulate plasma NO and myocardial VEGF, which may be related to its curative effect on AMI.
