Comparative study of the clinical effects of salvia miltiorrhiza injection and shengmai injection on chronic hepatitis B.
- Author:
Cui-xiang JIN
1
;
Jing YANG
;
Hai-feng SUN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Collagen Type IV; blood; Drug Combinations; Drug Therapy, Combination; Drugs, Chinese Herbal; administration & dosage; therapeutic use; Female; Hepatitis B, Chronic; blood; drug therapy; Humans; Hyaluronoglucosaminidase; blood; Injections, Intravenous; Laminin; blood; Liver Cirrhosis; prevention & control; Male; Middle Aged; Phytotherapy; Salvia miltiorrhiza; Treatment Outcome
- From: Chinese Journal of Integrated Traditional and Western Medicine 2006;26(10):936-938
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of Salvia miltiorrhiza Injection (SMI) and Shengmai Injection (SI) on liver function and fibrosis related indexes in patients with chronic hepatitis B.
METHODSSeventy-nine chronic hepatitis B patients were randomly divided into the SMI group (n=47) and the SI group (n=32), they were treated with SMI and SI respectively on the basis of conventional treatment. The therapeutic course was 35 days for both groups. The changes of main symptoms and physical signs were observed, and indexes of liver function and fibrosis including serum hyaluronidase, laminin, III type precollagen (PC-III) and IV type collagen (IV-C) were investigated before and after treatment.
RESULTSSymptoms, physical signs and liver functions were improved obviously in both SMI and SI groups, SI showed better effect than SMI (P < 0.05). The four liver fibrosis indexes declined significantly in the SMI group after treatment (P < 0.05), but no obvious change of those was found in the SI group (P > 0.05), showing significant difference between the two groups (P < 0.05). Conclusion SMI is effective in improving liver function and inhibiting liver fibrosis, and SI has even better effect in improving liver function than SMI, though it shows no anti-liver fibrosis effect.
