Study on independent factors on the prognosis of colorectal carcinoma: TNM stage, tumor budding, perineural invasion, peritumoral-lymphocytic infiltration and urine glucose.
- Author:
Fang-ying XU
1
;
Jian-kang DONG
;
Yi-min ZHU
;
Mei-juan QU
;
Fen-juan WANG
;
Yi-sen JIN
;
Guo-ping REN
;
Mao-de LAI
Author Information
- Publication Type:Journal Article
- MeSH: Aged; China; epidemiology; Colorectal Neoplasms; diagnosis; epidemiology; pathology; Female; Glycosuria; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Proportional Hazards Models; Regression Analysis; Retrospective Studies; Risk Factors
- From:Chinese Journal of Epidemiology 2005;26(5):366-369
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the influence of clinical and pathological-morphological parameters on the prognosis of colorectal carcinoma.
METHODSUnivariate and multivariate Cox proportional hazard model were used to study the influence of clinical and pathological-morphological factors on the prognosis in 226 colorectal carcinoma cases.
RESULTSUsing univariate analysis, data showed that the factors significantly related to disease prognosis would include: the depth of direct spread, vessel invasion, perineural invasion, tumor budding, peritumoral-lymphocytic infiltration, Crohn-like reaction, number of positive lymph nodes, distant metastasis, TNM stage and urine glucose. Multivariate Cox proportional hazard model showed that six factors were identified to be associated with higher relative-risk (RR), including: older age, advanced TNM stage, more severe budding, perineural invasion, less peritumoral-lymphocytic infiltration and urine glucose.
CONCLUSIONAge, TNM stage, tumor budding, perineural invasive, peritumoral-lymphocytic infiltration and urine glucose were independent predictors to the prognosis of colorectal carcinoma.
