Analysis on synergistic action between estrogen, progesterone and human papillomaviruses in cervical cancer.
- Author:
Jin-tao WANG
1
;
Er-sheng GAO
;
Yu-ying CHENG
;
Jian-wen YAN
;
Ling DING
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; China; epidemiology; DNA, Viral; analysis; Enzyme-Linked Immunosorbent Assay; Estrogens; blood; Female; Human papillomavirus 16; isolation & purification; Humans; Middle Aged; Papillomavirus Infections; Polymerase Chain Reaction; Progesterone; blood; Risk Factors; Uterine Cervical Neoplasms; blood; epidemiology; virology
- From:Chinese Journal of Epidemiology 2005;26(5):370-373
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effects of estrogen (E(2)) and progesterone (P) on cervical cancer and the synergistic action between estrogen, progesterone and human papillomaviruses (HPV).
METHODSHoted-start polymerase chain reaction (HS-PCR) was used to detect HPVs, HPV16 and ELISA was used to assay E(2) and P on 141 cases with cervical cancer and on 129 healthy controls.
RESULTSPositive rates of HPVs and HPV16 were 75.2% and 46.8% respectively in cervical cancer group, significantly higher than that in controls. Levels of estrogen and progesterone in case group were significantly higher than that in controls and a dose-responded relationship between the levels of estrogen and cervical cancer was revealed. Estrogen and HPV showed an additive interaction in the development of cervical cancer.
CONCLUSIONHPV16 infection played a principal role in the development of cervical cancer. The high levels of entogenous estrogen could increase the risk of cervical cancer and might serve as a cofactor in the development of HPV-induced cervical cancer.
