A case-control study on the mxA polymorphisms and susceptibility to severe acute respiratory syndromes.
- Author:
Hong-wei WANG
1
;
Jing HE
;
Pan-he ZHANG
;
Fang TANG
;
Tian-bao WANG
;
Yi-he LUAN
;
Hui LV
;
Zhao-yang CAO
;
Xiao-ming WU
;
Qiu-min ZHAO
;
Wei LIU
;
Wu-chun CAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Case-Control Studies; Female; GTP-Binding Proteins; genetics; Genetic Predisposition to Disease; Humans; Logistic Models; Male; Multivariate Analysis; Myxovirus Resistance Proteins; Polymorphism, Genetic; Severe Acute Respiratory Syndrome; genetics
- From: Chinese Journal of Epidemiology 2005;26(8):574-577
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between the genetic polymorphisms of myxovirus resistance 1 (MxA) gene and susceptibility to severe acute respiratory syndromes (SARS).
METHODSA case-control study was conducted and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the T/G polymorphism at position-88 in the mxA gene promoter. Information on related factors of SARS was collected using a pre-testing questionnaire. Univariate and multivariate logistic analyses were conducted with SPSS software package.
RESULTSSixty-six cases and sixty-four controls were selected for the study. Comparing with GG genotype, the proportion of GT genotype were significantly higher in the case group (81.3%) than that in the control group (62.5%)) with an OR (95% CI) of 2.700 (1.208-6.037). Multivariate logistic regression analysis revealed that the significant association remained after factors as wearing masks, protection gowns and eye-protection when contacting with SARS patient etc. were adjusted with an OR (95 % CI) of 2.911 (1.027-8.250).
CONCLUSIONmxA promoter-88G/T SNP might be confered to host genetic susceptibility to SARS in Chinese Han population.