Study on the intercellular molecule-1 polymorphisms in an Chinese population with myocardial infarction.
- Author:
Ming WANG
1
;
Yan LI
;
Ping-an ZHANG
;
Chao YANG
;
Ping-xia XIANG
;
Ye-sheng WEI
;
Xiao-yan LI
;
Cong-xin HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; genetics; Case-Control Studies; China; Female; Gene Frequency; Genotype; Humans; Intercellular Adhesion Molecule-1; genetics; Male; Middle Aged; Myocardial Infarction; genetics; Polymerase Chain Reaction; Polymorphism, Single Nucleotide
- From: Chinese Journal of Epidemiology 2005;26(9):702-706
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between intercellular adhesion molecule-1 (ICAM-1) gene + 12959G/A and + 13848A/G polymorphism and myocardial infarction (MI).
METHODSPolymerase chain reaction-sequence specific primers (PCR-SSP) technology and PCR-restriction fragment length polymorphism(PCR-RFLP) were used for the detection of ICAM-1 genotypes in 165 patients with MI(including acute MI and old MI) and 199 healthy controls. Plasma lipid levels and hyper sensitive C reactive protein (quantitive ELISA method was used) levels were measured in all subjects.
RESULTS+ 12959G/A polymorphism was not detected in our study. The frequencies of AA,AG and GG Genotypes of + 13848A/G were 58.2% and 45.7%, 37.0% among patients and 45.2%, 4.8% and 9.0% among controls,respectively. There were statistically significant differences in the distributions of the genotype frequencies (P<0.05) between two groups, and the relative risk suffered from MI of AA genotype was 1.651 times of the GG and GA genotype (OR = 1.651, 95% CI: 1.089-2.504).
CONCLUSIONThere was no + 12959G/A polymorphism found in Chinese people. The coding single nucleotide polymorphism + 13848 A/G in the exon 6 of ICAM-1 gene was associated to MI and the allele A might serve as a risk factor for MI in Chinese.