The application of counter-matching design in epidemiological research.
- Author:
Xiao-yun HU
1
;
Jian-hua WANG
Author Information
- Publication Type:Journal Article
- MeSH: Breast Neoplasms; epidemiology; etiology; genetics; radiotherapy; Epidemiologic Methods; Humans; Male
- From:Chinese Journal of Epidemiology 2005;26(9):723-725
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the application of counter-matching design in epidemiological research.
METHODSThrough elaboration of the study about gene-environment interactions in the etiology of breast cancer, methodology regarding counter-matching design and statistic methods was introduced.
RESULTSThis design improved the potential for detecting gene-environment interactions for diseases when both gene mutations and the environmental exposures of interest were rare in the general population.
CONCLUSIONCounter-matching appearsed to be more appropriate than most traditional epidemiologic methods for the study of interactions involving rare factors.