Local thermotherapy with rabdosia liquid as prophylactic measure for recurrence of superficial urinary bladder carcinoma: a non-randomized contemporary controlled study.
- Author:
Pei-yuan XU
1
;
Gao-xian ZHAO
;
Lian-sheng CHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Carcinoma, Transitional Cell; prevention & control; surgery; Drugs, Chinese Herbal; administration & dosage; Female; Humans; Hyperthermia, Induced; Isodon; chemistry; Male; Middle Aged; Neoplasm Recurrence, Local; prevention & control; Phytotherapy; Postoperative Period; Prospective Studies; Urinary Bladder Neoplasms; prevention & control; surgery
- From: Chinese Journal of Integrated Traditional and Western Medicine 2005;25(12):1115-1117
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the actions of local thermotherapy with rabdosia liquid and repeated perfusion of mitomycin C for the postoperative prophylaxis of superficial urinary bladder carcinoma.
METHODSIn the prospective non-randomized contemporary controlled study, 123 patients were divided into 2 groups. The patients in group A received local thermotherapy with rabdosia liquid starting from 1-2 months after operation, once tri-monthly for one year. Those in group B received intravesical perfusion of mitomycin C, starting from 2 weeks after operation, once weekly, six times in total, thereafter once monthly for one year. The recurrence rate, disease free interval, and adverse reaction after operation were observed.
RESULTSThe follow-up lasted for 10-45 months with the average of 28.6 +/- 5.8 months. The recurrence rates in group A and B were 5.0% and 14.3%, respectively. Significant difference was shown when compared by Kaplan-Meier analysis of disease free interval and the recurrence rate between the two groups (P < 0.05). The occurrence rates of cystitis, hematuria, vesical contracture, urethral stricture were 28.3%, 5.0%, 1.7%, 1.7%, respectively in group A, 25.4%, 4.8%, 0%, 0%, respectively in group B, showing no significant difference between the two groups (P > 0.05).
CONCLUSIONThe effect of local thermotherapy with rabdosia liquid is reliable in preventing the recurrence of superficial urinary bladder transitional cell carcinoma.